As part of a clever little blogmeme, the lovely Miss Meriko sent me a series of interview questions. I'm trying my darndest to avoid working on this packaging project for my graphics class, so what better reason to answer her queries?
What's your favorite molecule, and why?
I haven't got a favorite molecule in particular, but my favorite type of molecules are chiral molecules, also called enantiomers or "mirror molecules". Enantiomers are chemically identical, all the same atoms stuck together with all the same types of bonds, but since certain chemical bonds happen in such a way that they can be in clockwise or counterclockwise position in relation to each other, these types of molecules exhibit the property of chirality: they are right- or left- handed - mirror images of each other.
Naturally occurring amino acids (proteins), sugars and nucleic acids (DNA) all exist only as right- or left-handed forms. The left-handed form of glucose, for example, is still sweet like natural glucose, but it's undigestible - your body can't metabolize it. Lots of drugs are made with either the left-handed or right-handed isomer of a chiral molecule. If you get a formulation that isn't pure - if it has too much of the wrong isomer - you sometimes end up with negative (or at least undesired) effects like with "bad acid" (It's not speed in your LSD you damn hippie! it's just too much of the wrong enantiomer!) Thalidomide is also a chiral drug - one enantiomer had anti-nausea properties that cured morning sickness, the other caused terrible birth defects. A glitch in the manufacturing process meant too much of the wrong enantiomer, and wham - flipper babies.
Lately, our friends the drug companies are separating out and patenting enantiomers of different drugs: Nexium? Prilosec? Same thing. Same effect. Prilosec is a racemic mixture of R- and S- omeprazole, meaning it's a 50/50 mix of the right- and left-handed forms of the molecule. But the drug's patent expired in 2001, so they just re-released it as Nexium, with only one of the enantiomers, and patented it until 2014, with the same purple-pill packaging. Patients (and inattentive doctors) just go for the new "improved" purple pill, and pay twice as much for what is essentially the same drug. Ka-ching! Score one for AstraZeneca!
Anyway. There are lots of interesting properties of chiral chemicals which I will surely bore you to tears describing any further. I first got interested in them in high school after reading Martin Gardner's Annotated Alice books containing his deconstructions of the mathematical and scientific logic in Lewis Carroll's Alice in Wonderland and Through the Looking Glass. I was fascinated by the idea of mirror-image chemicals, ones that do one thing in our "natural" world, but have "looking glass" artificial counterparts that do something totally different. The book is an incredibly interesting and even an easy read (and he does a much better job of making math and science sound cool than I do). I highly recommend it if you haven't read it yet.
Dr. Johansen geeked out on o-chem a little too much there. Deep breath. Next question.
Tell me about the best meal you've ever had.
Also a hard one. I think it's a multi-way tie between the first time I ate at Vij's in Vancouver after the opening of the first art show I was ever in, ordering all the appetizers at once (goat cheese fondue!) at the
Your pictures seem to capture more of people than the meat on their bones. When you're looking through the lens of a camera at a person, what do you see?
I'm trying to keep their eyes in focus. I always fuck that part up. I think anything else is subconscious - I always get a little surprised when the film comes back.
What's the name of the best movie you have never seen?
2001. I've probably seen it in its entirety, but never in order, and never for longer than 20 minutes at a time. I always fall asleep.
What's your favorite dream?
I'm riding a ferris wheel with a friendly group of three-foot tall sentient Oreo cookies. We are hanging out, enjoying the nice summer evening, having a marvelous time, when the carnie stops the ride and makes the cookie I'm riding with get off the ride. Then he makes it leave because it's not a real Oreo cookie. It's a Hydrox cookie! I've been trying to analyze that one for years and I still can't figure out what it means.
Would you like to be next person in the interview chain? Send me a comment, I send you questions, you blog and the chain goes on...
Annotated Alice has become my standard gift to give to children of friends (too many) on appropriate birthdays; it's a gift a kid can keep coming back to for years, and while Gardner and I have fairly divergent opinions on pretty much everything, this is without question his shining moment.
I properly return to the hinternet on Friday (access from house again = site goes back up) and would be delighted to participate in some nature of interview, should my services be of use.
Posted by: db on July 14, 2003 08:57 AMI like that 2001 is the best movie you've ever seen, but you've never seen more than 20 minutes of it at a time! Honestly, that's not a bad way to take in that movie.
And I'll back you on the Vij's comments! I don't know if it was the food or the atmosphere or the surprise at finding such amazing food so unexpectedly in Vancouver, but it was some damn fine food! I'll never forget you steered us there...
Posted by: beca on July 14, 2003 03:08 PMI'd be interested in participating in an interview chain. Sounds like great interaction. Do send if you wish.
Posted by: rumbanik on July 22, 2003 11:37 AMI'd like to be interviewed, Kia dear.
Posted by: Chris A. on July 24, 2003 09:45 AM